Diet-induced mouse model of fatty liver disease and non-alcoholic
نویسندگان
چکیده
Amylin Pharmaceuticals, LLC. San Diego, CA 92121, USA 8 9 Running Head: Improved model and methods for characterizing NASH in mice 10 11 12 13 14 Both authors contributed equally. 15 *Corresponding Author: 16 Jason R. Clapper, PhD 17 Amylin Pharmaceuticals, LLC 18 9360 Towne Centre Drive 19 San Diego, CA 92121 20 Telephone: 858-754-4975 21 Fax: 858-642-7370 22 Email: [email protected] 23 24 25
منابع مشابه
The Effect of Aerobic Continuous Training on Myonectin, Insulin Resistance and Liver Enzymes in Rats with Nonalcoholic Fatty Liver Disease
Background. Non-alcoholic fatty liver disease, is the most common reason of liver disorders that can be controlled by dieting and regular physical activity. Objectives. The aim of this study was to investigate the effect of aerobic continuous training on serum levels of myonectin, insulin resistance and liver enzymes in rats with non-alcoholic fatty liver disease. Methods. Thirty-four male W...
متن کاملComparing Effects of Medication Therapy and Exercise Training with Diet on Liver enzyme Levels and Liver Sonography in Patients with Non-Alcoholic Fatty Liver Disease (NAFLD)
Background & Objectives: Non-alcoholic fatty liver disease, characterized by the deposition of fat in liver cells, can cause fibrosis, cirrhosis, and liver cell damage if not controlled. The aim of this study is to compare the effects of medication therapy and exercise training with diet on liver enzyme levels and liver sonography in patients with non-alcoholic fatty liver disease (NAFLD). Mate...
متن کاملProtective Effect of Aerobic Training along with Resveratrol on Mitochondrial Dynamics of Cardiac Myocytes in Animal Model of Non-alcoholic Fatty Liver Disease
Background & objectives: Non-alcoholic fatty liver disease (NAFLD) is associated with mitochondrial dysfunction. The aim of the present study was to examine the effect of aerobic training along with resveratrol on cardiac expression of OPA1 and DRP1 in NAFLD male rats. Methods: In this experimental study, forty eight male Wistar rats were classified into two groups: NAFLD (n=40) and Control-N...
متن کاملHealthy Diet for Fatty Liver in Children
Introduction: Non-alcoholic fatty liver disease (NAFLD) has become the most common cause of liver disease worldwide. It has been suggested that dietary composition plays a role in NAFLD pathogenesis; thus, changing dietary patterns may constitute a therapeutic resource even in the absence of weight reduction. The aim of this study was to identify the characteristic of suitable dietary pattern i...
متن کاملEffect of Ziziphus jujuba Mill., Cichorium intybus L. and Silybum marianum (L.) Gaertn. Combination Extract on Non-alcoholic Fatty Liver Disease in Rats
Background: Non-alcoholic fatty liver disease (NAFLD) includes a range of liver damage from early steatosis to cirrhosis. Although NAFLD prevalence in the world is increasing, but there is no effective treatment for it. Objective: The aim of this study was to evaluate the effect of combined extract of jujube, chicory and silymarin on NAFLD induced by high-fat diet (HFD) in rats. Method: In th...
متن کاملAssociation of Dietary Phytochemical Index and Anthropometric Risk Factors with Non-alcoholic Fatty Liver Disease in People with Diabetes
Background and Objectives: High prevalence of non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus results in deleterious complications and morbidities. Therefore, the aim of this study was to assess nutritional and anthropometrical risk factors in progression of non-alcoholic fatty liver disease in diabetic patients. Materials & Methods: Totally, 133 non-alcoholic fatty...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2013